02 / Eliminate cardiometabolic disorders
Pioneering curative therapies that address the root causes of heart failure and interconnected metabolic conditions could dramatically reduce the global disease burden.
Why it matters
Cardiometabolic conditions—including stroke, chronic heart failure, chronic kidney disease, hypertension, and type 2 diabetes—are the leading causes of death worldwide. Hypertension alone affects nearly half of adults in the United States[1], contributing to a cascade of comorbidities. Emerging therapies are poised to fundamentally reshape how we prevent and treat cardiometabolic disease. Tackling these disorders could halt or even reverse the processes that drive organ damage, significantly easing their global burden on both health systems and human lives.
What if cardiomyopathy could be prevented by stopping inflammation, fibrosis, and cell death before they begin, extending healthy lifespan for millions? What if we could restore kidney function to millions of patients with vast unmet need?
